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Canertinib dihydrochloride
CAS No. 289499-45-2
Canertinib dihydrochloride ( Canertinib;CI-1033 dihydrochloride;PD-183805 dihydrochloride;CI1033 dihydrochloride )
Catalog No. M13886 CAS No. 289499-45-2
A potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
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| 10MG | 43 | In Stock |
|
| 50MG | 61 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCanertinib dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay.
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DescriptionA potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay; displays no activity to PDGFR, FGFR, InsR, PKC, and CDK1/2/4; suppresses heregulin-stimulated tyrosine phosphorylation of erbB2, erbB3 and erbB4 with IC50 of 5, 14 and 10 nM, respectively, also inhibits expression of pp62c-fos in response to heregulin; shows high in vivo activity against A431 xenografts.Lung Cancer Discontinued
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SynonymsCanertinib;CI-1033 dihydrochloride;PD-183805 dihydrochloride;CI1033 dihydrochloride
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR;HER2/ErbB2
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number289499-45-2
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Formula Weight558.86
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Molecular FormulaC24H27Cl3FN5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
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Chemical Name2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smaill JB, et al. J Med Chem. 2000 Apr 6;43(7):1380-97.
2. Erlichman C, et al. Cancer Res. 2001 Jan 15;61(2):739-48.
3. Nyati MK, et al. Clin Cancer Res. 2004 Jan 15;10(2):691-700.
4. Slichenmyer WJ, et al. Semin Oncol. 2001 Oct;28(5 Suppl 16):80-5.
2. Erlichman C, et al. Cancer Res. 2001 Jan 15;61(2):739-48.
3. Nyati MK, et al. Clin Cancer Res. 2004 Jan 15;10(2):691-700.
4. Slichenmyer WJ, et al. Semin Oncol. 2001 Oct;28(5 Suppl 16):80-5.
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